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The present study investigated the effects of safflower (Carthamus tinctorius L.) extract on antioxidant levels in hyperlipidemic and hypertensive patients. The effect of safflower extract was compared with the values obtained from the same patients receiving the conventional lipid-lowering drugs (bezafibrate and niacin) and the calcium-antagonist (amlodipine). A total of 60 patients, 25 of which were hyperlipidemic and 25 hypertensive patients, were randomly assigned to the following 4 groups: a safflower extract group (n = 15), a bezafibrate group (n = 15), a niacin group (n = 15), and an amlodipine group (n = 15). After 8 wk of treatment, the serum lipid levels of the safflower extract group were significantly decreased as compared with baseline levels, whereas lipid levels in the bezafibrate and niacin groups were not significantly changed. The safflower extract also increased the plasma antioxidant capacity, whereas the other drugs did not affect the levels. These results suggest that safflower extract may be useful for reducing the oxidative stress in patients with hyperlipidemia and hypertension.Q:
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